colony stimulating factor 1 receptor

Cat No.	Product Name	Synonyms	Targets
T5586	CFMS Receptor Inhibitor II		c-Fms
	cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor		c-Fms
T10894	CSF1R-IN-1		c-Fms
	CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.		c-Fms
TQ0015	PRN1371		c-Fms , FGFR , CSF-1R
	PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).		c-Fms , FGFR , CSF-1R
T14380	AZD7507		CSF-1R , HER , Sodium Channel
	AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.		CSF-1R , HER , Sodium Channel
T6119	Sotuletinib	BLZ945	c-Fms , CSF-1R
	Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs.		c-Fms , CSF-1R
T13194	CSF1R-IN-2		c-Fms , c-Met/HGFR , Src
	CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).		c-Fms , c-Met/HGFR , Src
T10652	Vimseltinib	DCC-3014	c-Fms , CSF-1R , c-Kit
	Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).		c-Fms , CSF-1R , c-Kit
T7100	PLX5622	PLX-5622	c-Fms , CSF-1R
	PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.		c-Fms , CSF-1R
T2115	Pexidartinib	PLX-3397	Apoptosis , c-Fms , FLT , CSF-1R , c-Kit
	Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.		Apoptosis , c-Fms , FLT , CSF-1R , c-Kit
T2624	OSI-930	OSI 930	Apoptosis , c-Fms , Raf , VEGFR , FLT , CSF-1R , Src , c-Kit
	OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors.
T2659	GW2580	GW 2580,SC-203877	c-Fms
	GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.		c-Fms
T35570	Chiauranib	CS2164	c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
	Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...		c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
T4315	Ki20227		c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit
	Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.		c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit
T15199	Edicotinib	JNJ-527,JNJ-40346527	c-Fms , FLT , CSF-1R , c-Kit
	Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote...		c-Fms , FLT , CSF-1R , c-Kit
T6930	Pazopanib Hydrochloride	GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala	c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy
	Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, resp...		c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy
T6289	Dovitinib	TKI258,CHIR-258	VEGFR , FGFR , FLT , PDGFR , c-Kit
	Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to E...		VEGFR , FGFR , FLT , PDGFR , c-Kit
T2514	Linifanib	ABT-869,RG3635,AL-39324	Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...
T6028	PF 477736	PF 00477736,PF-477736,PF-736,PF-00477736,PF477736	c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T1925	PLX647		c-Fms , c-Kit
	PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).		c-Fms , c-Kit
T76776	Emactuzumab	RO 5509554,RG 7155	c-Fms , TAM Receptor
	Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating fa...		c-Fms , TAM Receptor